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KMID : 1134820190480101165
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Journal of the Korean Society of Food Science and Nutrition
2019 Volume.48 No. 10 p.1165 ~ p.1171
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Anti-Diabetic Activity of Edible Insect Gryllus bimaculatus Extracts in Insulin-Deficient Diabetic Mice
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Cho Hyung-Taek
Sim Kyu-Sang
Kim Yeo-Na
Chang Moon-Han
Kim Tae-Wan
Lee Seung-hwan
Lee Dong-Hee
Kim Jun-Ho
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Abstract
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The benefits of edible insects as an alternative animal protein source in the future has recently drawn significant attention. This study examined the anti-diabetic potential of edible insect Gryllus bimaculatus in streptozotocin (STZ)-induced insulin-deficient diabetic mice. Diabetes was induced by a multiple-low-dose STZ treatment after two weeks of the oral administration of G. bimaculatus water extracts (GBE) at 150 mg/kg. The administration of GBE reduced the hyperglycemia, delayed the cumulative incidence of diabetes, and improved glucose tolerance in the STZ-treated mice. Moreover, GBE protected the pancreatic islet against STZ-induced disruption of the islet architecture and function by inhibiting β-cell apoptosis in mice. Importantly, these protective effects were associated with the suppression of the mitogen-activated protein kinase- and nuclear factor-kappa B-mediated signaling pathways in the pancreas. These findings provide novel mechanistic insight into the protective effects of GBE against pancreatic islet dysfunction in insulin-deficient diabetes mellitus.
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KEYWORD
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Gryllus bimaculatus, streptozotocin, diabetes, pancreatic islet, β-cell apoptosis
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